Decision Circuits Journal Club

We're discussing recent papers in systems neuroscience with a focus on quantitative behavior, cortical dynamics, cell-types, and neuromodulation.

We meet bi-weekly on Monday at 9.30am on Campus Nord (between Luisenstraße and Philippstraße).

If you'd like to join the discussion please let Antonio know and we'll add you to our e-mail reminders with details on upcoming dates (about one e-mail per meeting/week).

Format

  • Quick round of summaries of recently encountered papers:
  • Intro of the presented paper’s authors (first, last, or in between) and how this relates to past authors and topics
  • OR: intro of guest speaker
DateTimePresenterTitleDOIPrimer
08.07.20249:30 amLilly von KalckreuthNishio, M., Kondo, M. et al. Medial prefrontal cortex suppresses reward-seeking behavior with risk of punishment by reducing sensitivity to reward. Sec. Decision Neuroscience 18 (2024).https://doi.org/10.3389/fnins.2024.1412509
27.05.20249:30 amAntonio Leede Jong, J.W., Liang, Y., Verharen, J.P.H. et al. State and rate-of-change encoding in parallel mesoaccumbal dopamine pathways. Nat Neurosci 27, 309–318 (2024).https://doi.org/10.1038/s41593-023-01547-6
06.05.20249:30 amVictoria VegaLuo, Q., Kanen, J.W., Bari, A. et al. Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making. Neuropsychopharmacol. 49, 600–608 (2024).https://doi.org/10.1038/s41386-023-01762-6
22.04.20249.30 amEric LonerganDavid Martin, Angel Delgado, Donna Calu The psychedelic, DOI, increases dopamine release in nucleus accumbens to predictable rewards and reward cueshttps://doi.org/10.1101/2024.03.29.587390
03.04.20244 pmAntonio LeeBlanco-Pozo, M., Akam, T. & Walton, M.E. Dopamine-independent effect of rewards on choices through hidden-state inference. Nat Neurosci 27, 286–297 (2024).https://doi.org/10.1038/s41593-023-01542-x
20.03.20244 pmClaire SturgillSchneider, S., Lee, J.H. & Mathis, M.W. Learnable latent embeddings for joint behavioural and neural analysis. Nature 617, 360–368 (2023).https://doi.org/10.1038/s41586-023-06031-6CEBRA paper
21.02.20244 pmLuna StrauchBernklau, T.W., Righetti, B., Mehrke, L.S. et al. Striatal dopamine signals reflect perceived cue–action–outcome associations in mice. Nat Neurosci (2024).https://doi.org/10.1038/s41593-023-01567-2
31.01.20244 pmDariya KassybayevaGupta, D., DePasquale, B., Kopec, C.D. et al. Trial-history biases in evidence accumulation can give rise to apparent lapses in decision-making. Nat Commun 15, 662 (2024). https://doi.org/10.1038/s41467-024-44880-5
17.01.20244 pmVictoria VegaHattori, R., Hedrick, N.G., Jain, A. et al. Meta-reinforcement learning via orbitofrontal cortex. Nat Neurosci 26, 2182–2191 (2023).https://doi.org/10.1038/s41593-023-01485-3
29.11.20234 pmEric LonerganRahbarnia…Flechter (2023). Effects of psilocybin, the 5-HT2A receptor agonist TCB-2, and the 5-HT2A receptor antagonist M100907 on visual attention in male mice in the continuous performance testhttps://doi.org/10.1007/s00213-023-06474-9
15.11.20234 pmLilly von KalckreuthMusall…Churchland (2023). Pyramidal cell types drive functionally distinct cortical activity patterns during decision-makinghttps://doi.org/10.1038/s41593-022-01245-9
01.11.20234 pmJérémie Sibille (AG Kremkow)Sibille…Kremkow (2022). Efficient mapping of the thalamocortical monosynaptic connectivity in vivo by tangential insertions of high-density electrodes in cortexhttps://doi.org/10.1101/2022.12.28.522000
18.10.20234 pmNina GrimmeHill…Schultz(2023). Dopamine signals encode internally determined subjective value regardless of externally indicated reward attributeshttps://doi.org/10.1101/2023.01.20.524896
04.10.20234pmGreg KnollGore…Deisseroth (2023). Orbitofrontal cortex control of striatum leads economic decision-makinghttps://doi.org/10.1038/s41593-023-01409-1Choice information in the OFC is relayed to the DMS to lead accurate economic decision-making
20.09.20234pmAntonio LeeGrove…Knight (2023). Dopamine subsystems that track internal states. Naturehttps://doi.org/10.1038/s41586-022-04954-0Distinct dopamine neurons in the VTA respond to ‘internal states’ tracking hydration and nutrition
14.09.20239.30amDariya KassybayevaYun…Parker (2023). Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neuronshttps://doi.org/10.1038/s41593-023-01390-9This paper uses the novel hallucination-like perception task (cf Schmack et al, Science) to study striatal circuits for psychosis and antipsychotics.
07.09.20239.30amGreg KnollSohn … Jazayeri (2019). Bayesian Computation through Cortical Latent Dynamics. Neuronhttps://doi.org/10.1016/j.neuron.2019.06.012Population states in primate PFC encode both the prior and temporal estimate to guide behavior
15.06.20239.30amVictoria VegaShen..Glimcher (2023). Flexible control of representational dynamics in a disinhibition-based model of decision making. eLifehttps://doi.org/10.7554/eLife.82426Spiking neural network model that includes both inhibitory and disinhibitory cell types reproduces decision-making features
25.05.20239.30amEric LonerganVargas..Olson (2023). Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Sciencehttps://doi.org/10.1126/science.adf0435Psychedelics unfolder their neuroplastic effects not via regular membrane-bound 5HT2A receptors, but by going into the cell
20.04.20239.30amEricTorrado Pacheco … Moghaddam (2023). Acute psilocybin enhances cognitive flexibility in rats. Neurophsychopharmacologyhttps://doi.org/10.1038/s41386-023-01545-zPsilocybin changes reversal learning in a 2A dependent way
13.04.20239.30amLillyHyun..Kwon (2023). Serotonin in the orbitofrontal cortex enhances cognitive flexibility. BioRxivhttps://doi.org/10.1101/2023.03.09.531880Serotonin specifically in OFC changes speed of reversal learning
23.03.20239.30amVictoriaAklan…Atasoy (2023). Dorsal raphe serotonergic neurons suppress feeding through redundant forebrain circuits. Molecular Metabolismhttps://doi.org/10.1016/j.molmet.2023.101676Specific dorsal raphe 5HT neurons suppress feeding (to LH and BNST)
16.02.20239.30amVictoriaDiehl,Redish (2023). Differential processing of decision information in subregions of rodent medial prefrontal cortex. eLifehttps://doi.org/10.7554/eLife.82833mPFC subregion coding of decision variables during economic decisions
09.02.20239.30amGregPandarinath…Susillo (2018). Inferring single-trial neural population dynamics using sequential auto-encoders. Nature Methodshttps://doi.org/10.1038/s41592-018-0109-9Novel method to model single-trial spike trains using RNN-based autoencoders.
02.02.20239.30amEricPomrenze … Malenka (2022). Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal. Neuronhttps://doi.org/10.1016/j.neuron.2022.09.0245HT in the striatum is important for social deficits related to addiction
26.01.20239.30amLillyPaquelet … Miller (2022). Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors. Neuronhttps://doi.org/10.1016/j.neuron.2022.05.015Different subpopulation of dorsal raphe 5HT neurons (grouped by projection) are differentially sensitive to reward/social/shock/anxiety cues
12.01.20239.30amVictoriaJeong … Namboodiri (2022). Mesolimbic dopamine release conveys causal associations. Sciencehttps://doi.org/10.1126/science.abq6740A novel, causal framework and model for association learning (as opposed to RL)
9.30amAntonioKlein-Fluegge, … Rushworth (2022). Medial and orbital frontal cortex in decision-making and flexible behavior. Neuronhttps://doi.org/10.1016/j.neuron.2022.05.022Value and choice coding along OFC regions
20.10.20229.30amGregSylwestrak…Sussillo, Deisseroth (2022) Cell-type-specific population dynamics of diverse reward computations. Cellhttps://doi.org/10.1016/j.cell.2022.08.019Functional groups of neurons in the habenula encode reward prediction, outcome, and history and are modelled with cell-type LFADS

This notion page is synced with https://torbenottlab.org/decision-circuits-journal-club.