Decision Circuits Journal Club
We're discussing recent papers in systems neuroscience with a focus on quantitative behavior, cortical dynamics, cell-types, and neuromodulation.
We meet bi-weekly on Monday at 9.30am on Campus Nord (between Luisenstraße and Philippstraße).
If you'd like to join the discussion please let Antonio know and we'll add you to our e-mail reminders with details on upcoming dates (about one e-mail per meeting/week).
Format
- Quick round of summaries of recently encountered papers:
- Intro of the presented paper’s authors (first, last, or in between) and how this relates to past authors and topics
- OR: intro of guest speaker
Date | Time | Presenter | Title | DOI | Primer |
22.04.2024 | 9.30 am | Eric Lonergan | David Martin, Angel Delgado, Donna Calu The psychedelic, DOI, increases dopamine release in nucleus accumbens to predictable rewards and reward cues | https://doi.org/10.1101/2024.03.29.587390 | |
03.04.2024 | 4 pm | Antonio Lee | Blanco-Pozo, M., Akam, T. & Walton, M.E. Dopamine-independent effect of rewards on choices through hidden-state inference. Nat Neurosci 27, 286–297 (2024). | https://doi.org/10.1038/s41593-023-01542-x | |
20.03.2024 | 4 pm | Claire Sturgill | Schneider, S., Lee, J.H. & Mathis, M.W. Learnable latent embeddings for joint behavioural and neural analysis. Nature 617, 360–368 (2023). | https://doi.org/10.1038/s41586-023-06031-6 | CEBRA paper |
21.02.2024 | 4 pm | Luna Strauch | Bernklau, T.W., Righetti, B., Mehrke, L.S. et al. Striatal dopamine signals reflect perceived cue–action–outcome associations in mice. Nat Neurosci (2024). | https://doi.org/10.1038/s41593-023-01567-2 | |
31.01.2024 | 4 pm | Dariya Kassybayeva | Gupta, D., DePasquale, B., Kopec, C.D. et al. Trial-history biases in evidence accumulation can give rise to apparent lapses in decision-making. Nat Commun 15, 662 (2024). | https://doi.org/10.1038/s41467-024-44880-5 | |
17.01.2024 | 4 pm | Victoria Vega | Hattori, R., Hedrick, N.G., Jain, A. et al. Meta-reinforcement learning via orbitofrontal cortex. Nat Neurosci 26, 2182–2191 (2023). | https://doi.org/10.1038/s41593-023-01485-3 | |
29.11.2023 | 4 pm | Eric Lonergan | Rahbarnia…Flechter (2023). Effects of psilocybin, the 5-HT2A receptor agonist TCB-2, and the 5-HT2A receptor antagonist M100907 on visual attention in male mice in the continuous performance test | https://doi.org/10.1007/s00213-023-06474-9 | |
15.11.2023 | 4 pm | Lilly von Kalckreuth | Musall…Churchland (2023). Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making | https://doi.org/10.1038/s41593-022-01245-9 | |
01.11.2023 | 4 pm | Jérémie Sibille (AG Kremkow) | Sibille…Kremkow (2022). Efficient mapping of the thalamocortical monosynaptic connectivity in vivo by tangential insertions of high-density electrodes in cortex | https://doi.org/10.1101/2022.12.28.522000 | |
18.10.2023 | 4 pm | Nina Grimme | Hill…Schultz(2023). Dopamine signals encode internally determined subjective value regardless of externally indicated reward attributes | https://doi.org/10.1101/2023.01.20.524896 | |
04.10.2023 | 4pm | Greg Knoll | Gore…Deisseroth (2023). Orbitofrontal cortex control of striatum leads economic decision-making | https://doi.org/10.1038/s41593-023-01409-1 | Choice information in the OFC is relayed to the DMS to lead accurate economic decision-making |
20.09.2023 | 4pm | Antonio Lee | Grove…Knight (2023). Dopamine subsystems that track internal states. Nature | https://doi.org/10.1038/s41586-022-04954-0 | Distinct dopamine neurons in the VTA respond to ‘internal states’ tracking hydration and nutrition |
14.09.2023 | 9.30am | Dariya Kassybayeva | Yun…Parker (2023). Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons | https://doi.org/10.1038/s41593-023-01390-9 | This paper uses the novel hallucination-like perception task (cf Schmack et al, Science) to study striatal circuits for psychosis and antipsychotics. |
07.09.2023 | 9.30am | Greg Knoll | Sohn … Jazayeri (2019). Bayesian Computation through Cortical Latent Dynamics. Neuron | https://doi.org/10.1016/j.neuron.2019.06.012 | Population states in primate PFC encode both the prior and temporal estimate to guide behavior |
15.06.2023 | 9.30am | Victoria Vega | Shen..Glimcher (2023). Flexible control of representational dynamics in a disinhibition-based model of decision making. eLife | https://doi.org/10.7554/eLife.82426 | Spiking neural network model that includes both inhibitory and disinhibitory cell types reproduces decision-making features |
25.05.2023 | 9.30am | Eric Lonergan | Vargas..Olson (2023). Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science | https://doi.org/10.1126/science.adf0435 | Psychedelics unfolder their neuroplastic effects not via regular membrane-bound 5HT2A receptors, but by going into the cell |
20.04.2023 | 9.30am | Eric | Torrado Pacheco … Moghaddam (2023). Acute psilocybin enhances cognitive flexibility in rats. Neurophsychopharmacology | https://doi.org/10.1038/s41386-023-01545-z | Psilocybin changes reversal learning in a 2A dependent way |
13.04.2023 | 9.30am | Lilly | Hyun..Kwon (2023). Serotonin in the orbitofrontal cortex enhances cognitive flexibility. BioRxiv | https://doi.org/10.1101/2023.03.09.531880 | Serotonin specifically in OFC changes speed of reversal learning |
23.03.2023 | 9.30am | Victoria | Aklan…Atasoy (2023). Dorsal raphe serotonergic neurons suppress feeding through redundant forebrain circuits. Molecular Metabolism | https://doi.org/10.1016/j.molmet.2023.101676 | Specific dorsal raphe 5HT neurons suppress feeding (to LH and BNST) |
16.02.2023 | 9.30am | Victoria | Diehl,Redish (2023). Differential processing of decision information in subregions of rodent medial prefrontal cortex. eLife | https://doi.org/10.7554/eLife.82833 | mPFC subregion coding of decision variables during economic decisions |
09.02.2023 | 9.30am | Greg | Pandarinath…Susillo (2018). Inferring single-trial neural population dynamics using sequential auto-encoders. Nature Methods | https://doi.org/10.1038/s41592-018-0109-9 | Novel method to model single-trial spike trains using RNN-based autoencoders. |
02.02.2023 | 9.30am | Eric | Pomrenze … Malenka (2022). Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal. Neuron | https://doi.org/10.1016/j.neuron.2022.09.024 | 5HT in the striatum is important for social deficits related to addiction |
26.01.2023 | 9.30am | Lilly | Paquelet … Miller (2022). Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors. Neuron | https://doi.org/10.1016/j.neuron.2022.05.015 | Different subpopulation of dorsal raphe 5HT neurons (grouped by projection) are differentially sensitive to reward/social/shock/anxiety cues |
12.01.2023 | 9.30am | Victoria | Jeong … Namboodiri (2022). Mesolimbic dopamine release conveys causal associations. Science | https://doi.org/10.1126/science.abq6740 | A novel, causal framework and model for association learning (as opposed to RL) |
9.30am | Antonio | Klein-Fluegge, … Rushworth (2022). Medial and orbital frontal cortex in decision-making and flexible behavior. Neuron | https://doi.org/10.1016/j.neuron.2022.05.022 | Value and choice coding along OFC regions | |
20.10.2022 | 9.30am | Greg | Sylwestrak…Sussillo, Deisseroth (2022) Cell-type-specific population dynamics of diverse reward computations. Cell | https://doi.org/10.1016/j.cell.2022.08.019 | Functional groups of neurons in the habenula encode reward prediction, outcome, and history and are modelled with cell-type LFADS |
This notion page is synced with https://torbenottlab.org/decision-circuits-journal-club.